Olmesartan Medoxomil Versus Losartan in Patients With Hypertension

Daiichi Sankyo

Status and phase: Completed; Phase 3

Conditions: Essential Hypertension

Treatments: Drug: losartan potassium; Drug: olmesartan medoxomil

Study type: Interventional

Funder types: Industry

Identifiers

NCT00857285

TSP-866/01

Details and patient eligibility

About

The purpose of this study is to determine the efficacy and safety of oral administration of olmesartan medoxomil compared to losartan in subjects with mild to moderate hypertension.

Enrollment: 130 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diastolic BP 95 mm Hg - 114 mm Hg inclusive
• No participation in any clinical trial for the last 3 months

Exclusion criteria

• Secondary hypertension
• Malignant hypertension
• Severe arterial hypertension
• Significant cardiovascular disease
• History or clinical evidence of cerebrovascular, gastrointestinal, hematological, hepatic disease, myocardial infarction, or severe liver disorder
• Clinical evidence of renal disease, poorly controlled diabetes, known malabsorption syndromes, psychiatric/emotional problems

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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130 participants in 2 patient groups

1

Experimental group

Description:

olmesartan medoxomil

Treatment:

Drug: olmesartan medoxomil

2

Active Comparator group

Description:

losartan potassium

Treatment:

Drug: losartan potassium