Omega-3 and Aspirin in Periodontal Regeneration (PR)

October 6 University

Status and phase: Completed; Phase 2

Conditions: Periodontal Disease

Treatments: Drug: Sugar pill; Other: Regenerative therapy (omega 3 PUFA plus low dose aspirin)

Study type: Interventional

Funder types: Other

Identifiers

NCT01113528

October 6 U 196222 (Other Identifier)

HHDA-1962

Details and patient eligibility

About

To evaluate the efficacy of systemic administration of omega 3 PUFA plus low dose aspirin as an adjunctive therapy to regenerative modality of grade II furcation defects in periodontitis patients.

Full description

In this study, we tested the hypothesis that the administration of omega 3 PUFA plus low dose aspirin would augment the results following regenerative therapy of furcation defects in chronic periodontitis patients.

Enrollment: 40 patients

Sex: All

Ages: 35 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• suffering moderate to sever chronic periodontitis and displaying at least a single grade II furcation defect according to Glickman's classification 1953, determined by both clinical and radiographic examinations;
• free from systemic diseases known to influence the periodontal condition and not receiving any medication known to affect the periodontal status;
• have not receive any periodontal therapy for a minimum of 6 months prior to the study.

Exclusion criteria

• Known hypersensitivity or allergy to one of the used medications
• Pregnancy or lactation
• Heavy smoking (more than 10cigarretes/day)
• History of alcohol abuse
• Participation in other clinical trials

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

Regenerative therapy

Experimental group

Treatment:

Other: Regenerative therapy (omega 3 PUFA plus low dose aspirin)

Sugar pill

Placebo Comparator group

Treatment:

Drug: Sugar pill