Omega-3 Fatty Acids and Nutritional Support in Gastrointestinal Cancer

Maimónides Biomedical Research Institute of Córdoba

Status: Enrolling

Conditions: Sarcopenia

Treatments: Dietary Supplement: omega-3; Dietary Supplement: Standard

Study type: Interventional

Funder types: Other

Identifiers

NCT06015971

Sarcopenia omega3

Details and patient eligibility

About

Sarcopenia is a frequent complication in patients with cancer and chronic diseases, it is characterized by decreased muscle strength and fatigue due to reduced skeletal muscle mass, which is accompanied by atrophy and decreased quality of muscle tissue. In all cases, it negatively impacts treatment tolerance, clinical outcomes and survival, in consequence, quality of life of these patients decreases while morbidity, mortality and costs increase. In this context, appropriate nutritional screening and early nutrition support are extremely recommended, to this aim, in some cases, oral nutritional supplements (ONS) are necessary; ONS could have a standard formula or be enriched with specific nutrients (arginine, glutamine, branched chain amino acids, n-3 fatty acids, and nucleotides), which can modulate the activity of the immune system and provide an additional benefit beyond the nutritional support, this intervention type is called immunonutrition. Despite these possible benefits, their utility has been proven in few clinical scenarios, for example in with patients with upper gastrointestinal cancer undergoing surgical resection; based on this, current guidelines recommend that patients should receive oral/enteral nutritional support with an specific formula enriched in immunonutrients (with arginine, n-3 fatty acids or nucleotides) , but there is a lack of evidence for supporting its use in other clinical conditions including patients with cancer that receive systemic treatment

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Patients with Gastrointestinal tumor undergoing systemic treatment (chemo-radio-immuno therapy or their combination)
• Body weight loss >5% in the previous three months or >10% in the previous six months
• Both sexes
• Age between 18-85 y-old.

Exclusion criteria

• Life expectancy < 2 weeks
• MDRD < 15 mL/min
• End-stage liver disease
• Any musculoskeletal, cardiovascular and/or neurological disorders that could affect exercising.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

standard hypercaloric, hyperproteic oral supplement

Active Comparator group

Treatment:

Dietary Supplement: Standard

omega-3 enriched oral supplement

Experimental group

Treatment:

Dietary Supplement: omega-3