Omega-3 Supplementation for Smell Dysfunction

Stanford University

Status: Completed

Conditions: Smell Dysfunction; Sellar/Parasellar Tumor

Treatments: Dietary Supplement: Omega-3

Study type: Interventional

Funder types: Other

Identifiers

NCT02529332

IRB00076285

Details and patient eligibility

About

Omega-3 supplementation has been shown to have neuroprotective and potentially anti-inflammatory properties in both central and peripheral nerve injuries. The investigators are studying to see if omega-3 supplementation will affect olfactory (smell) function in patients with olfactory dysfunction following endoscopic removal of pituitary tumors.

Enrollment: 110 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• sellar/parasellar tumor scheduled to undergo endoscopic transnasal transsphenoidal resection
• 18 years of age or older
• English speaking

Exclusion criteria

• Currently using blood thinning agents (aside from NSAIDs or cardioprotective ASA)
• elevated AST, ALT, or alk phos >10% outside of normal range, if randomized to omega-3 group
• diabetes, if randomized to omega-3 group and not already on omega-3 prescribed by another provider
• unable to provide informed consent due cognitive deficiencies

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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110 participants in 2 patient groups

Omega-3 Supplementation Group

Experimental group

Description:

Omega-3 supplementation

Treatment:

Dietary Supplement: Omega-3

Control Group

No Intervention group