On Dose Efficiency of Modern CT-scanners in Chest Scans

University Hospital Augsburg

Status: Completed

Conditions: Pulmonary Embolism; Pulmonary Disease; Lung Cancer; Pneumonia; Aortic Stenosis

Treatments: Diagnostic Test: CT Scan using an Energy-Integrating Detector CT (128 slice MDCT); Diagnostic Test: CT Scan using an Energy-Integrating Detector CT (20-slice MDCT); Diagnostic Test: Imaging on Scanner with Spectral Imaging Capabilities

Study type: Interventional

Funder types: Other

Identifiers

NCT04996693

21-0368

Details and patient eligibility

About

CT scans of the chest / thorax are of great importance both in the initial diagnosis and in the follow-up of pulmonary or thoracic diseases. As an example, CT angiography of the pulmonary arteries (CTPA) is worldwide considered to be gold standard test in patients with a suspicion for pulmonary embolism.

The aim of this study is to measure and compare dose efficiency of modern CT scanners for unenhanced and contrast-enhanced scan protocols of the chest/thorax. Patients who are referred for a CT of the chest/thorax will be randomly assigned to one of the three CT scanners currently in use at our institution.

Enrollment: 958 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient is referred for an unenhanced CT OR contrast-enhanced CT of the chest/thorax confirmed by a board-certified radiologist ('justifying indication' according to German/European radiation protection law) AND
• patient is at least 18 years of age AND
• patient (is able to give informed consent and) has given informed consent.

Exclusion criteria

• high degree of medical urgency (i.e. patient cannot be consented for iv contrast according to routine procedures)
• known or suspected pregnancy, or lactating . contraindications for contrast agent (renal failure, allergy, hyperthyroidism)

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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958 participants in 3 patient groups

Scanner 1

Other group

Description:

Imaging performed on scanner 1: Photon-Counting Detector CT

Treatment:

Diagnostic Test: Imaging on Scanner with Spectral Imaging Capabilities

Scanner 2

Other group

Description:

Imaging performed on scanner 2: Energy-Integrating Detector CT (128-slice)

Treatment:

Diagnostic Test: CT Scan using an Energy-Integrating Detector CT (128 slice MDCT)

Scanner 3

Other group

Description:

Imaging performed on scanner 3: Energy-Integrating Detector CT (20-slice)

Treatment:

Diagnostic Test: CT Scan using an Energy-Integrating Detector CT (20-slice MDCT)