On-line Cognitive Training for Parkinson's Disease

Università degli Studi di Brescia

Status: Unknown

Conditions: Parkinson Disease

Treatments: Other: Neuronation; Other: Aspecific online games

Study type: Interventional

Funder types: Other

Identifiers

NCT04259827

19/01

Details and patient eligibility

About

Application of online cognitive training in patients affected by Parkinson's disease and mild cognitive impairment. The treatment consists of a 6-week on-line cognitive training preceded and followed by neurological, neuropsychological and motor assessment.

Full description

At the recruitment, participants will undergo a neurological visit, a neuropsychology assessment (2 tests for each considered cognitive domain: memory, attention, visuospatial, executive function, language) and a motor assessment with wearing sensors under supervised conditions.

In the treatment arm only, patients will have the Neuronation application installed on their personal technology device (smartphone or tablet) and are asked to complete 4 training session three times a week. Each session is composed of 5 exercises from one out of 4 cognitive domains: Memory, Attention, Speed and Reasoning. The training is tailor made, the complexity of the exercises is adjusted online, based on the patient's performance.

Participants are re-assessed at the end of the 6-week cognitive training (T1) to find out its effects on cognition and motor ability. The same assessment is administered also after 1 (T2) and 3 (T3) months from the end of the cognitive training to test long-term effects.

Enrollment: 60 estimated patients

Sex: All

Ages: 40 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ease of use of at home internet connection
• Active presence of a caregiver to help with the use of the App
• Sufficient physical ability to use a technological device
• Signature of informed consent

Exclusion criteria

• Presence of systemic pathologies potentially responsible for cognitive deficits
• Presence of pathologies of the Central Nervous system potentially associated with cognitive deficits
• No access to internet connection
• Cognitive rehabilitation within the previous 6 months
• Major depression (assessed by Beck Depression Inventory at baseline)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 3 patient groups

Online cognitive training

Experimental group

Description:

6-week online personalized cognitive training using Neuronation platform 4 training session three times a week. Each session is composed of 5 exercises from one out of 4 cognitive domains: Memory, Attention, Speed and Reasoning

Treatment:

Other: Neuronation

Aspecific online games

Active Comparator group

Description:

online application not created with a cognitive training purpose, for the same amount of time and frequence as the experimental group

Treatment:

Other: Aspecific online games

No online cognitive training

No Intervention group

Description:

normal clinical follow-up without cognitive training or gaming