Oncologic Outcomes and Toxicities of Salvage Treatment in Patients With Locoregionally Recurrent Breast Cancer (SALT-LRR)

Samsung Medical Center

Status: Enrolling

Conditions: Breast Cancer

Treatments: Other: Salvage treatment (surgery and/or radiation therapy)

Study type: Observational

Funder types: Other

Identifiers

NCT05933733

2023-05-023

Details and patient eligibility

About

The purpose of this study is to evaluate clinical outcomes and adverse events of salvage treatment for locoregional recurrence of breast cancer.

The main questions it aims to answer are:

• Clinical outcomes after salvage treatment for locoregional recurrence
• Adverse events and quality of life after salvage treatment for locoregional recurrence
• Patient characteristics and treatment specifics which are related to the clinical outcomes and/or adverse events
• Molecular signature associated with treatment resistance

Participants will be assessed by multi-dimensional methods during and after radiation therapy:

• Assessment for the disease status (disease-free or recurrence) including physical and radiologic examination
• Assessment for the adverse events according to CTCAE version 5.0
• Assessment for the molecular signature using residual tissue after pathologic diagnosis
• Assessment for the quality of life using questionnaires (BREAST-Q)

Enrollment: 190 estimated patients

Sex: Female

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female patients with age 18 to 100.
• Previous standard definitive treatment for initial breast cancer
• Locoregional recurrence without distant metastasis
• Planned salvage treatment for locoregional recurrence
• Informed consent of the participant

Exclusion criteria

• Not anticipated for complying the study protocol

Trial design

190 participants in 1 patient group

Salvage treatment after locoregional recurrence

Description:

Participants who previously completed standard treatment for breast cancer and experienced locoregional recurrence alone will be undergo salvage treatment including surgery and/or radiation therapy.

Treatment:

Other: Salvage treatment (surgery and/or radiation therapy)