Oncological and Functional Outcomes in Lower Limb Osteosarcoma Pediatric Patient

Changye Zou

Status: Completed

Conditions: Outcome; Osteosarcoma; Lower Limb Injury; Pediatric

Treatments: Other: Retrospective analysis

Study type: Observational

Funder types: Other

Identifiers

NCT06162962

Changye Zou

Details and patient eligibility

About

Retrospective analysis of specific characteristics of complications and long-term oncological and function outcomes in lower-limb osteosarcoma pediatric patients.

Full description

Clinical and functional outcomes were compared based on age groups, surgical methods, type of prosthesis, and primary tumor location. Patients were divided into the Low-age group (≤10 years old) and the High-age group (>10 years old). Overall Survival rate (OS), Progression-Free Survival rate (PFS), and prosthesis survival rate were assessed using Kaplan-Meier curves, and non-parametric survival analysis (log-rank test) was used for comparison. The incidence of complications, local relapse rate (LRR), metastasis rate, final limb-salvage and amputation rate, and Musculoskeletal Tumor Society (MSTS) score of different independent groups were further evaluated using χ2 test or Fisher's exact test, and t-test was employed to evaluate the measurement data.

Enrollment: 345 patients

Sex: All

Ages: 4 to 14 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Diagnosed lower limb osteosarcoma patients under the age of 14;
2. Performing tumor resection treatment in our hospital;
3. There is complete clinical registration data available.

Exclusion criteria

1. Not undergoing surgical treatment in our hospital;
2. Age older than 14 years old;
3. No available clinical registration data or lost follow-up patients;
4. Non lower limb osteosarcoma patients.

Trial design

345 participants in 5 patient groups

age groups

Description:

The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded.

Treatment:

Other: Retrospective analysis

surgical methods

Description:

The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded.

Treatment:

Other: Retrospective analysis

type of prosthesis

Description:

The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded.

Treatment:

Other: Retrospective analysis

primary tumor location

Description:

The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded.

Treatment:

Other: Retrospective analysis

Enneking stage

Description:

The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded.

Treatment:

Other: Retrospective analysis