Oncological and Functional Outcomes of Laparoscopic Partial Nephrectomy in Renal Cell Carcinoma Stages T1 Versus T2a: Prospective Comparative Study.

S

Sohag University

Status

Not yet enrolling

Conditions

Renal Cell Carcinoma

Treatments

Procedure: laparoscopic partial nephrectomy

Study type

Interventional

Funder types

Other

Identifiers

NCT05486871
Soh-Med-22-07-20

Details and patient eligibility

About

RCC represents around 3% of all cancers, with the highest incidence occurring in Western countries . Within the several RCC risk factors identified, smoking, obesity, and hypertension are most strongly associated with RCC . The EUA guidelines recommend PN for patients with T1 tumors, as PN preserved kidney function better after surgery, thereby potentially lowering the risk of development of cardiovascular disorders as well as improving overall survival(OS) for PN compared to RN, there is very limited evidence on the optimal surgical treatment for patients with larger renal masses (T2) . Currently, the upper limit of PN indications remains undefined and is determined by an individual surgeon's expertise and preference. The degree of variability in the choice between PN and RN for a given tumor increases with tumor size. Surgeons committed to nephron-sparing are likely to expand the indications of PN, while those concerned with increased morbidity and doubtful of the clinical relevance of a moderate decrease in renal function are likely to perform RN, regardless of tumor size .

Enrollment

30 estimated patients

Sex

Male

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with localized RCC ≤ 10 cm in preoperative contrast enhanced imaging(T1 and T2a).

Exclusion criteria

  • Patients who had other tumors
  • benign tumors
  • clinically unfit
  • metastatic RCC
  • patients with Clinical T2b or higher tumors,
  • tumors with maximum diameter > 10cm

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

30 participants in 2 patient groups

renal cell carcinoma stages T1
Active Comparator group
Description:
laparoscopic partial nephrectomy in renal cell carcinoma stage T1
Treatment:
Procedure: laparoscopic partial nephrectomy
renal cell carcinoma stages T2a
Active Comparator group
Description:
laparoscopic partial nephrectomy in renal cell carcinoma stage T2a
Treatment:
Procedure: laparoscopic partial nephrectomy

Trial contacts and locations

0

Loading...

Central trial contact

Ahmed M Attia, assisstent lecturer; Mohamed s Saleem, professor

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location

Resources

© Copyright 2024 Veeva Systems