Ondansetron and Blood Coagulation

Seoul National University

Status: Enrolling

Conditions: Blood Coagulation Disorder

Treatments: Drug: 20 ul of ondansetron; Drug: 0.2 ul of ondansetron; Drug: 2 ul of ondansetron; Drug: 0 ul of ondansetron

Study type: Interventional

Funder types: Other

Identifiers

NCT04499274

B-2008/631-305

Details and patient eligibility

About

Ondansetron may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of ondansetron. The investigators therefore will perform the present study to measure the effect of ondansestron on the blood coagulation pathway according to the drug concentration level using a thromboelastography test.

Enrollment: 12 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy vonlunteers
• Age: 20 to 65 years
• Body weight > 50 kg
• Volunteers who provided informed consent

Exclusion criteria

• Hematologic disease
• Anticoagulant medication

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 4 patient groups

0 ng/ml

Experimental group

Description:

Blood specimen which was added 0 ul of ondansetron

Treatment:

Drug: 0 ul of ondansetron

200 ng/ml

Experimental group

Description:

Blood specimen which was added 0.20 ul of ondansetron

Treatment:

Drug: 0.2 ul of ondansetron

2000 ng/ml

Experimental group

Description:

Blood specimen which was added 2 ul of ondansetron

Treatment:

Drug: 2 ul of ondansetron

20000 ng/ml

Experimental group

Description:

Blood specimen which was added 20 ul of ondansetron

Treatment:

Drug: 20 ul of ondansetron