Ondansetron Prior Spinal Anaesthesia

Assiut University

Status: Completed

Conditions: Cesarean Section

Study type: Observational

Funder types: Other

Identifiers

NCT06431568

IRB0000871252

Kuwait MOH (Other Identifier)

Details and patient eligibility

About

Since Ondansetron is commonly used during cesarean deliveries to treat nausea and vomiting, this study will observe the correlation between ondansetron administration and effect on hemodynamics in order to confirm that the use of Ondansetron can reduce incidence of hypotension and bradycardia associated with spinal in cesarean section, and to identify the optimal timing and dose for administration.

Full description

Hypothesis:

Administration of ondansetron prior to spinal anesthesia can attenuate hypotension and bradycardia.

Aim:

Since Ondansetron is commonly used during cesarean deliveries to treat nausea and vomiting, this study will observe the correlation between ondansetron administration and effect on hemodynamics in order to confirm that the use of Ondansetron can reduce incidence of hypotension and bradycardia associated with spinal in cesarean section, and to identify the optimal timing and dose for administration.

Objectives:

• Primary outcome: incidence of hypotension after spinal anaesthesia in the patients who received Ondansetron and those who did not
• Secondary outcome : use of vasopressors , bradycardia , timing of administration of Ondansetron wether it is more or less than five minutes prior to the administration of anesthesia.

Enrollment: 400 patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pregnant patients undergoing elective caesarean section

Exclusion criteria

• Preeclampsia
• Eclampsia
• Hypertension
• Diabetes

Trial design

400 participants in 1 patient group

Intravenous Ondansetron for patients undergoing Cesarean section under spinal Anesthesia

Description:

Pregnant patients undergoing elective caesarean section with no co-morbidities will receive intravenous ondansetron