One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators

University of Zurich (UZH)

Status: Completed

Conditions: Thoracic Surgery With One-lung Ventilation

Treatments: Drug: Sevoflurane/propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT00515905

StV 20-2004

Details and patient eligibility

About

One-lung ventilation; organ protection; volatile anesthetics

One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis will be tested in this study:

1. Are inflammatory mediators increased in the re-ventilated lung after short-period pulmonary collapse?

2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated lung? Therefore, this study will elucidate the potential protective effect of a volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory compartment of the lung, i.e. the alveolar epithelium.

   • Trial with immunomodulatory product / biological

Enrollment: 76 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Thoracic surgery (thoracotomy, thoracoscopy) with one-lung ventilation

Exclusion criteria

• Immunosuppressive therapy
• Ongoing inflammatory processes

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)