One Week of Magnesium Supplementation Lowers IL-6, Perceived Pain and Increases Post Exercise Blood Glucose in Response to Downhill Running

University of Worcester

Status: Completed

Conditions: Magnesium Deficiency

Treatments: Dietary Supplement: Magnesium oxide; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT04216836

SH17180029-R

Details and patient eligibility

About

This study investigated the effect of magnesium supplementation on exercise performance and functional recovery in recreational endurance athletes in conjunction with measures of blood glucose, lactate, IL-6 and sIL-6R.

Full description

Magnesium status can directly affect circulating glucose concentrations both during and post exercise. In addition, magnesium supplementation has been shown to reduce circulating IL-6 concentrations post exercise in humans. It is conceivable that such observations are linked through the role of IL-6 in glucose regulation, possibly in combination with sIL-6R. Together, magnesium intake may have the potential to effect exercise performance and recovery through glucose availability. This in turn may be connected to the production of IL-6 and sIL-6R which have been established to influence exercise fatigue and perception of pain (muscle soreness).

Enrollment: 9 patients

Sex: Male

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Regular recreational runner, running around 3 times per week
• Capable of running 10 km in ~ 40 minutes.

Exclusion criteria

• Any signs or symptoms of cardiovascular issues.
• Any recent form of injury or illness.
• Currently, or in the last 3 months, have consumed multivitamin supplements
• Currently, or in the last 3 months, have consumed anti-inflammatory medications.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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9 participants in 2 patient groups

High magnesium diet (SUP condition)

Experimental group

Description:

Participants followed a low magnesium diet \<260mg/day and consumed 500 mg/day of magnesium oxide. This was separated into 3 capsules, which were consumed at 6 hr intervals each day (8am, 2pm and 8pm). The supplementation period was 1 week.

Treatment:

Dietary Supplement: Magnesium oxide

Low magnesium diet (CON condition)

Experimental group

Description:

Participants followed a low magnesium diet \<260mg/day and consumed 500 mg/day of placebo (cornflour). This was separated into 3 capsules, which were consumed at 6 hr intervals each day (8am, 2pm and 8pm). The supplementation period was 1 week.

Treatment:

Dietary Supplement: Placebo