Online Adaptive Radiation Therapy for Rectal Cancer

Chinese Academy of Medical Sciences & Peking Union Medical College

Status and phase: Not yet enrolling; Phase 2; Phase 1

Conditions: Rectal Cancer

Treatments: Radiation: Online adaptive radiation therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05911789

ART-rectal cancer

Details and patient eligibility

About

In the present study, the investigators will evaluate the efficacy, toxicities, and of online adaptive radiation therapy (ART) for patients with rectal cancer treated with neoadjuvant chemoradiotherapy.

Enrollment: 15 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. ≥18 years old;
2. Diagnose with rectal cancer;
3. T3-T4 or N+, and no distant metastasis
4. Neoadjuvant chemoradiotherapy intended;
5. Surgery is expected after neoadjuvant therapy;
6. ECOG score 0-2, expected to lie in the treatment bed for at least half an hour;

Exclusion criteria

1. With contraindications to rectal MRI;
2. Received surgery, radiotherapy or chemotherapy for rectal cancer;
3. History of pelvic radiotherapy.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

Online adaptive radiation therapy

Experimental group

Description:

Patients receive adaptive radiotherapy therapy and concurrent chemotherapy.

Treatment:

Radiation: Online adaptive radiation therapy