Oocyte Survival After Vitrification in an Open or Closed Device With Closed Storage.

Universitair Ziekenhuis Brussel

Status: Completed

Conditions: Survival; Embryo Quality

Treatments: Device: Cryotop SC device; Device: CBSvit HS device

Study type: Interventional

Funder types: Other

Identifiers

NCT01952184

2013/777

Details and patient eligibility

About

The survival rate (and embryo quality) of donor oocytes with two commercially available devices.

Full description

Donor sibling oocytes will be vitrified with two commercially available devices. The first device is closed vitrification with closed storage and the second device is open vitrification with closed storage. Oocyte acceptors receive oocytes from both devices. With the increase in cooling rate generated by the open vitrification (second device), we expect to get an increase in survival rate of 10%. Besides this, embryo quality will be assessed with oocytes obtained from both devices.

Enrollment: 48 patients

Sex: Female

Ages: 18 to 36 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Donor: ≤36 years old on day of oocyte retrieval
• Donor: ≥ 6 mature oocytes

Exclusion criteria

• Donor: < 6 mature oocytes

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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48 participants in 2 patient groups

closed vitrification with closed storage

Active Comparator group

Description:

Half of the oocytes of every donor will be vitrified with the Cryo Bio Systems High Security vitrification (CBSvit HS) device; the standard device in our lab.

Treatment:

Device: CBSvit HS device

open vitrification with closed storage

Experimental group

Description:

Half of the oocytes of every donor will be vitrified with the Cryotop closed system (Cryotop SC).

Treatment:

Device: Cryotop SC device