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This is an open-label study of safety, tolerability, pharmacokinetics and pharmacodynamics of Auriхim multiple doses in patients with recurrent/ refractory В-cell, CD20-positive non-Hodgkin lymphoma of low tumor grade or with follicular lymphoma, as well as in patients non-treated before for В-cell, CD20-positive non-Hodgkin lymphoma of low tumor grade.
The study will be carried out in 4-6 Russian and Belarussian sites. The study will be consisted of screening period, induction (obligatory) phase and supporting (non-obligatory) phase of the investigational therapy and post-treatment follow-up period.
Enrollment
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Inclusion criteria
To participate in the clinical study, patients must comply to the following criteria:
Signed patient's information sheet and informed consent form
Males and females aged ≥ 18 years
The expected survival time not less than 6 months, with no need of an urgent intervention to eliminate life-threatening complications
Histologically and clinically confirmed at the screening diagnosis of В-cell, CD20-positive non-Hodgkin lymphoma of low tumor grade or follicular lymphoma, according to WHO's (World Health Organization) classification as of year 2008, namely:
Patients did not receive any therapy for the main disease, or disease recurrence, or refractivity after the previous therapy
II, III or IV disease stage according to Ann Arbor's classification and indications for immunotherapy, in the Investigator's opinion
The patient must have at least one 2-view measurable lesion (size by the long axis > 1,5 cm and size by the short axis > 1,0 cm, measured by means of CT scanner), that did not undergo radiotherapy in the past or appeared again in the course of the previous treatment.
Patients must have an ECOG status of 0 - 2
Requirements for laboratory parameters determined below:
Hematology: Absolute neutrophil count:
Platelets:
Hemoglobin: ≥ 1500/mm3 (1.5 x 109 cells/L)
Liver function: Total bilirubin:
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT): ≤ 1.5 x ULN
≤ 2.5 x ULN Renal function: GFR (according to Cocroft-Golt formula): > 30 ml/min.
The patients must be practicing effective methods of birth control during the whole period of the study and 12 months after the last administration of the investigational product.
Exclusion criteria
The patient will be considered ineligible for the study in case he/she has any criteria listed here below:
Chronic lymphocytic leukemia
CNS invasion now or in the history (lymphoma of CNS or lymphomatous meningitis)
Treatment by chemotherapeutic agents or radiotherapy within 4 weeks before screening, treatment by nitrosourea and mitomycin C within 6 weeks before screening or presence of ongoing toxicities of ≥ II grade according to CTCAE, related to the prior therapy (excluding alopecia)
Prior treatment by MAb (monoclonal antibodies) within 3 months before screening
Concomitant immunosupressive therapy and systemic treatment by corticosteroids on the moment of screening.
Clinically significant cardiovascular diseases:
Peripheral neuropathy ≥ III severity level
Primary or secondary immunodeficiency now or in the history
Presence of antibodies to human immunodeficiency virus (HIV), or hepatitis С virus (HCV), active hepatitis B
Tuberculosis during last 5 years or positive result of the Quantiferon test
Active infection within 4 weeks before screening
Surgical interference (excluding biopsy of lymphatic nodes) within 4 weeks before screening
History of other malignancies with the exception of cervical carcinoma in situ or skin basal-cell carcinoma, that had undergone surgical removal and treatment within ≥ 5 years before screening
Uncontrolled concomitant diseases and conditions, including mental or social, which, in the Investigator's opinion, may prevent the patient from participation in the study.
Hypersensitivity to any of medicinal agents used in this study, to their compounds or to murine proteins, as well as significant, in the Investigator's opinion, allergic reactions in the history
Participation in other clinical studies or administration of other investigational products within 30 days before screening, or ongoing adverse reactions to any investigational product
Drug or alcohol abuse on the moment of screening or in the past, which, in the Investigator's opinion, makes the patient unsuitable for participation in the study.
Pregnant or lactating women, or women who plan to get pregnant during the clinical study; women of childbearing potential (not sterile and in postmenopause less than 2 years) who do not practice effective methods of birth control. Effective methods of birth control include usage of:
Inability to read or write, unwillingness to understand and comply with the procedures of the study protocol, as well as any other concomitant medical or serious mental conditions, that make the patient unsuitable for participation in the clinical study, limit the validity of informed consent receipt or may affect the patient's ability to participate in the study -
Primary purpose
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7 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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