Open-Label Trial of the Use of Minocycline in the Treatment of Asthma

State University of New York - Downstate Medical Center

Status and phase: Completed; Phase 2

Conditions: Asthma

Treatments: Drug: Minocycline

Study type: Interventional

Funder types: Other

Identifiers

NCT00536042

open mino

Details and patient eligibility

About

The tetracycline minocycline has, in addition to its anti-infective properties, anti-inflammatory properties which may be of use in the treatment of asthma. This study evaluates the benefit of minocycline as add-on therapy for adults with asthma.

Full description

Adult asthmatic (ages 18 to 75 years) with a history of moderate to severe persistent asthma are given minocycline capsules as add-on therapy for treatment of asthma. Treatment is for one year. Dosing begins at 150 mg twice daily and can increase every eight weeks by 50mg BID to a maximum of 250 mg twice daily. This is as per patient tolerance as minocycline can cause dizziness and stomach upset, as well as effects of liver enzymes.Patients undergo routine blood toxicity screens every two months, at which time spirometry is performed Exclusion criteria: pregnant women (adequate contraception in mandated) previous history of hypersensitivity to tetracyclines, chronic liver disease Outcome measures: improvement in FEV1 and other spirometric parameters, decrease in oral steroid requirements, change in total serum IgE, improvement in quality of life

Enrollment: 14 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults (ages 18 to 75 yrs)
• Mild to severe asthma
• History of or current oral steroid use to control asthma atopy

Exclusion criteria

• Pregnant women

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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14 participants in 1 patient group

minocycline

Experimental group

Description:

addition of minocycline to standard asthma care as add-on therapy: 150 mg bid to 250 mg bid for up to one year

Treatment:

Drug: Minocycline