Opioid Agonist and Antagonist Effects on Opioid Dependence
Status and phase
Conditions
Treatments
Details and patient eligibility
About
The purpose of this study is to examine the acute agonist and antagonist effects of a full opioid agonist medication, an opioid antagonist medication, and a partial opioid agonist medication in individuals who have different levels of physical opioid dependence.
Full description
The pharmacological effects of opioids in opioid dependent individuals can vary as a function of the characteristics of the opioid being studied (e.g., whether it is an agonist, partial agonist, or antagonist; the dose administered; and the route of administration). Another important set of factors influencing the effects produced by opioids is the characteristics of the organism to which the opioid is being administered. One such characteristic is the level of physical dependence in individuals.
Participants in this study will be maintained on different dose levels of an opioid agonist (methadone). The participant will be challenged with a prototypic opioid agonist, antagonist, and a mixed agonist-antagonist with partial agonist features in order to determine the effects that each has on the human body.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Active opioid dependence
- Qualifies for opioid agonist treatment (e.g., methadone or buprenorphine)
- Fulfills DSM-IV diagnostic criteria for opioid dependence
Exclusion criteria
- Significant medical problems, including insulin dependent diabetes mellitus
- Non-substance use psychiatric disorders (e.g., schizophrenia)
- Currently seeking treatment for substance abuse
Trial design
Primary purpose
Allocation
Interventional model
Masking
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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