Opioid-free Anesthesia in Thoracic Surgery (VATOFA)

Civil Hospices of Lyon

Status: Completed

Conditions: Thoracic; Surgery

Treatments: Other: Post-operative care

Study type: Observational

Funder types: Other

Identifiers

NCT04246099

VATOFA

Details and patient eligibility

About

No study has been conducted to demonstrate the feasibility and safety of an Opioid-Free Anesthesia (OFA) protocol compared to Opioid-Based Anesthesia (OBA) in thoracic surgery, at risk for intense post-operative pain, to improve patient care. The aim of the present study was to evaluate the effect of OFA on post-operative opioids consumption, pain and the post-operative period after lobectomy by Video-Assisted Thoracoscopy Surgery (VATS). systems.

Investigators perform a retrospective, single-center study in 2019. Patients were divided into two groups: OFA (with dexmedetomidine) or OBA (sufentanyl).

Investigators analyse the total postoperative opioid consumption in the 48 h after surgery. Investigators asses pain intensity in the 48 h after surgery, operative hemodynamic stability, Post-Operative Pain (POP) in Post-Anesthesia Care Unit (PACU) and POP on day 30.

All data are available in the medical record

Hypothesis: OFA can reduce post-operative opioids consumption, pain in lobectomy by video-assisted thoracoscopy surgery (VATS).

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All consecutive patients admitted for lobectomy or wedge video-assisted thoracoscopy
• Opioid Free Anesthesia (OFA) administration was left to the discretion of the attending anesthetist according to his or her practices and habits.
• age 18 or over
• lobectomy or wedge resection by Video-Assisted Thoracoscopy Surgery (VATS)

Exclusion criteria

• toxicomania,
• epidural analgesia use,
• thoracotomy conversion
• Patient-Controlled Analgesia with morphine (PCA)
• Patient who object to take part of the study.

Trial design

100 participants in 2 patient groups

Group opioid free anesthesia

Description:

Patient benefit of the opioid free anesthesia protocol

Treatment:

Other: Post-operative care

Group opioid based anesthesia

Description:

Patient don't benefit of the opioid free anesthesia protocol

Treatment:

Other: Post-operative care