Opioid-free Anesthesia in VATS Lung Resection

Peking University

Status: Unknown

Conditions: Opioid Free Anesthesia

Treatments: Procedure: Paravertebral block+Anterior serratus plane block; Drug: opioid free anesthesia; Drug: opioid based anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT04507165

2020PHB031

Details and patient eligibility

About

A comparison of incidences of postoperative opioid-related adverse effects and recovery parameters in patients undergoing video-assisted thoracoscopic surgery (VATS) lung resection receiving opioid or opioid-free general anesthesia (OFA).

Full description

Video-assisted thoracoscopic surgery (VATS) lung resection is traditionally performed under general anesthesia with opioid-based analgesia. It is associated with higher incidences of respiratory depression, hypotension, postoperative nausea and vomiting (PONV), dizziness, constipation and urinary retention, and more severe acute postoperative pain.

The purpose of our study is to compare the opioid-free general anesthesia with the opioid-based general anesthesia with respect to the primary outcome measures of the total incidence of opioid-related adverse effects (including respiratory depression, hypotension, PONV and dizziness) and secondary outcome measures of incidence of intraoperative and postoperative cardiovascular complications, pain relief, analgesic requirement , and other postoperative recovery parameters [e.g. duration of tracheal extubation, departing from post-anaesthesia care unit (PACU), exhaust, defecation, and stay in hospital postoperatively].

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Undergoing VATS lung resection.
• American Society of Anesthesiologists (ASA) physical status I-II.
• Agreed to participate in the trial.

Exclusion criteria

• Pregnant women
• ASA phase III or above.
• Undergoing emergency surgery.
• Planning for thoracotomy.
• Adults protected by law (under judicial protection, guardianship or supervision), people who deprived of their liberty.
• Patients who have received general anesthesia.
• Atrioventricular block, sinus node block or intraventricular block.
• Sinus bradycardia (heart rate is less than 60 beats/min).
• Preoperative hypotension (systolic blood pressure is less than 90mmHg)
• Combined with urolithiasis, Meniere syndrome, and vertebral artery stenosis
• Combined with cerebrovascular disease.
• Contraindication to NSAIDs drug.
• Allergic to anesthetics.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

opioid-free general anesthesia

Experimental group

Description:

under opioid-free general anesthesia

Treatment:

Drug: opioid free anesthesia

Procedure: Paravertebral block+Anterior serratus plane block

opioid based general anesthesia

Active Comparator group

Description:

under opioid based general anesthesia

Treatment:

Drug: opioid based anesthesia

Procedure: Paravertebral block+Anterior serratus plane block