Opioid Free Anesthesia on the Quality of Early Recovery (opioid-free)

Capital Medical University

Status

Not yet enrolling

Conditions

Opioid-free Anesthesia

Treatments

Drug: T group

Study type

Interventional

Funder types

Other

Identifiers

NCT05577962

opioid-free anesthesia

Details and patient eligibility

About

To analyze and compare the effect of OFA scheme and traditional balanced anesthesia scheme on QoR15 after thyroidectomy, and further clarify the safety and rationality of OFA scheme in perioperative application of thyroid surgery.

Full description

OFA scheme (group T) was given dexamethasone 8mg for anti-inflammatory and antiemetic before operation, flurbiprofen axetil 50mg for preemptive analgesia, and dexmedetomidine was infused under ECG monitoring at an initial rate of 0.5 μ G/kg (more than 10min), then changed to 0.2ug/kg/h, and stopped infusion 20 minutes before operation closure. Before induction, lidocaine (1mg/kg), esketamine (0.5mg/kg), propofol (1-2mg/kg) and rocuronium (0.6mg/kg) were infused slowly, and endotracheal intubation was carried out when the anesthetic was fully effective and the BIS value was about 40. After successful intubation, an experienced anesthesiologist guided by ultrasound performed bilateral superficial cervical plexus block with 0.5% ropivacaine and injected 3-4ml at two points respectively; During the operation, sevoflurane (MAC1.0 - 1.4) was used to maintain the depth of anesthesia; The routine anesthesia group (Group C) was induced to give sufentanil 0.3-0.5ug/kg, propofol 1-2mg/kg, rocuronium 0.6mg/kg slowly, and then intubated when the anesthetic was fully effective and the BIS value was about 40. Remifentanil was continuously pumped 0.1-0.2ug/kg during operation min； Combined with sevoflurane (MAC 0.8-1) to maintain the depth of anesthesia.

Enrollment

160 estimated patients

Sex

All

Ages

18 to 99 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Patients undergoing elective thyroidectomy under general anesthesia
>18 year old
The informed consent form has been signed
American Society of Anesthesiologists (ASA) anesthesia grade I - II

Exclusion Criteria:

Long term use of opioids
Long term use of NSAIDs
Have a history of psychosis, epilepsy, preoperative anxiety, depression, and emotional management disorders
Patients with increased gastric contents reflux and respiratory tract aspiration
Operation time>3h
Severe liver and kidney insufficiency, cardiac insufficiency, bradycardia with 2 ° II or 3° atrioventricular block
Those who are allergic to or have contraindications to drugs that may be used in the test
Those who cannot cooperate with researchers