Opioid Maintenance Medications Comparison Study

Johns Hopkins University

Status and phase: Completed; Phase 2

Conditions: Opioid Dependence

Treatments: Drug: LAAM. buprenorphine and methadone

Study type: Interventional

Funder types: Other

Identifiers

NCT00344812

BPR-95-07-24-03

Details and patient eligibility

About

A 17 week, double-blind, randomized, parallel group, four arm design outpatient study comparing LAAM, buprenorphine and two dose levels of methadone for the treatment of opioid dependence.

Sex: All

Ages: 21 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion

• age 21 to 55 years
• diagnosis of opioid dependence by criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV)
• evidence of recent opioid use on toxicologic screening

Exclusion

• serious medical or psychiatric illness requiring long-term medication
• positive pregnancy test

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind