Opioid Reduced Anesthesia With Parasternal CATheters on Postoperative Delirium After Cardiac Surgery (ORACAT)

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Cardiac Disease

Treatments: Other: collection of datas

Study type: Observational

Funder types: Other

Identifiers

NCT05880615

IRBN452022/CHUSTE

Details and patient eligibility

About

PostOperative Delirium (POD) is the most common neuropsychiatric complication following cardiac surgery and may be related to morphine consumption. PostOperative Delirium (POD) prolongs hospital and intensive care unit (ICU) length of stay (LOS) and increases morbidity and mortality. No study has been conducted to demonstrate the effect of regional anesthesia using catheters inserted before sternotomy.

Full description

This study investigate the effect of an enhanced recovery protocol using regional anesthesia on PostOperative Delirium (POD) onset.

Enrollment: 100 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age over 18
• Admitte for scheduled cardiac surgery with sternotomy under cardiopulmonary bypass (CPB) for coronary artery bypass grafting (CABG), surgical correction of valve disease (aortic, mitral or tricuspid) or combined surgery (coronary artery bypass grafting (CABG) and valve replacement).

Exclusion criteria

• Age over 85,
• emergency surgery or heart transplant,
• body mass index (BMI) more than 40 kg.m-2
• reoperation
• Renal insufficiency with glomerular filtration rate (GFR) less than 30 mL.min-1
• left ventricular ejection fraction less than 30%
• respiratory insufficiency with arterial pressure of oxygen less than 60 mmHg
• hepatic insufficiency with prothrombin rate less than 30% or cirrhosis
• chronic hyperglycemia not controlled
• pregnancy
• cognitive impairment chronic use of opioids or drug addiction
• epilepsy
• guardianship
• allergy to locals anesthesics or any drugs

Trial design

100 participants in 2 patient groups

opioid reduced anesthesia with parasternal catheters inserted before sternotomy

Description:

Patients with opioid reduced anesthesia with parasternal catheters inserted before sternotomy will be included.

Treatment:

Other: collection of datas

Opioid Anesthesia (OA)

Description:

Patients with Opioid Anesthesia (OA) will be included.

Treatment:

Other: collection of datas