Opioid System Cerebral Activity in Endurance Sportswomen - Addiction or Denutrition ? [11C]Diprenorphine PET Study

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Sports Nutritional Sciences

Treatments: Other: [11C]diprenorphine

Study type: Interventional

Funder types: Other

Identifiers

NCT02112695

1208051

2013-004733-32 (EudraCT Number)

Details and patient eligibility

About

Abnormal opioid system have been identified in addictive behavior and activity of the opioid system has also shown a strong link with the nutritional balance. A significant increase in endorphin levels was noticed after exercise, proportional to the duration and intensity of this activity. One brain imaging study showed an increase in opioid activity in athletes after endurance training. However , a decrease in opioid tone related to receptor desensitization in the brain has been raised in the sport and it is possible to feel like , the subject must perform physical exercise more frequently . Consequently, in order to deepen the hypothesis of addiction in high-level sport , the brain opioid activity should be assessed pre- training compared to a group of sedentary control subjects .

Preliminary results of a previous study the investigators are conducting on anorexia nervosa (AN ) show abnormalities that appear to be involved in self addiction anorexia nervosa and the regulation of gonadal function. However, the relation of cause and effect between these anomalies and undernutrition remains to be determined . Given the addictive component in the endurance sport and the variability of the nutritional status of its practitioners , evaluation of brain activity in these subjects could provide additional answers.

Enrollment: 35 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

For High-level sportswomen :

• 18-35-year-old
• High-level sportswomen
• BMI>19kg/m2
• Absence of eating disorders
• In pre-competition period
• Signature of written consent

For controls :

• 18-35-year-old
• Sedentary normal weight women
• BMI>19kg/m2
• Normal nutritional markers
• Absence of eating disorders or other psychiatric or organic diseases

Exclusion criteria

• Oral contraception
• Heart failure
• Neuroleptics, antiparkinson drugs, alpha-methyl-dopa, beta blockers, inhibitors of monoamine oxidase-A or MOA-B, tricyclic antidepressants, selective serotonin reuptake inhibitor, thyme-regulators (lithium), anticonvulsant drugs, codeine, morphine, drugs containing tramadol, dopaminergic drugs

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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35 participants in 2 patient groups

sportswomen

Experimental group

Description:

3 micrograms \[11C\]diprenorphine

Treatment:

Other: [11C]diprenorphine

control subjects

Experimental group

Description:

3 micrgrams \[11C\]diprenorphine

Treatment:

Other: [11C]diprenorphine