Optic Nerve Head Strain as Biomarker for Glaucoma

Johns Hopkins University

Status: Enrolling

Conditions: Glaucoma, Open-Angle

Treatments: Device: Images of eye at 2 eye pressures

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT06240312

IRB00431247

Details and patient eligibility

About

The investigators will test the hypothesis that images of the optic nerve head taken a 2 different eye pressures will yield strain estimates that are predictive of the course of glaucoma.

Full description

Existing glaucoma patients and suitable control adults will be imaged with an FDA-approved optical coherence tomography instrument. Those who are imaged at 2 different eye pressures will generate biomechanical strain estimates. These will be compared to visual field and retinal nerve fiber layer measurements over time. The investigators expect that baseline strain and their changes over time will be associated with progression rate of glaucoma damage, providing a biomarker for susceptibility.

Enrollment: 130 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Existing glaucoma patients of Johns Hopkins

Exclusion criteria

• Inability to perform imaging
• illiterate
• hearing impaired
• non-English speakers

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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130 participants in 1 patient group

All subjects

Other group

Description:

Each subject will be imaged at two different times and eye pressures

Treatment:

Device: Images of eye at 2 eye pressures