Optic Nerve Sheath Diameter Difference Between Different Injection Volume

Keimyung University

Status: Completed

Conditions: Optic Nerve Sheath Diameter

Treatments: Procedure: thoracic epidural catheterization

Study type: Interventional

Funder types: Other

Identifiers

NCT04412109

2020-01-081

Details and patient eligibility

About

Valid method of indirect measurement of intracranial pressure is using optic nerve sheath diameter. Different volume of injection is known to affect the degree of increase of intracranial pressure.

This study is desinged to measure the changes of optic nerve sheath diameter and cerebral oxygenation when different volume of normal saline was injected.

Full description

Previous study showed that different volume of injections (1.0 ml/kg vs. 1.5 ml/kg) during caudal anesthesia showed siginifiant increase of optic nerve sheath diameter in group of high volumes. Increase of ICP can result in harmful effect including reduced cerebral flow and oxygen saturation. Also, increase of ICP can cause headache, syncope and transient loss of visual acuity. The proven and valid method of measuring ICP indirectly is using optic nerve sheath diameter.

This study was designed to examine the changes of optic nerve sheath diameter and cerebral oxygenation when different volume of normal saline was injected.

Enrollment: 50 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• lung cancer
• liver cancer
• stomach cancer
• pancreas cancer
• gallbladder cancer

Exclusion criteria

• coagulopathy
• infection
• previous spine fusion at thoracic level
• previous brain lesion causing increased intracranial pressure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 3 patient groups

injection of low volume of saline

Active Comparator group

Description:

low volume (5 cc) saline injection during thoracic epidural catheterization

Treatment:

Procedure: thoracic epidural catheterization

injection of intermediate volume of saline

Active Comparator group

Description:

intermediate volume (10 cc) saline injection during thoracic epidural catheterization

Treatment:

Procedure: thoracic epidural catheterization

injection of high volume of saline

Active Comparator group

Description:

high volume (20 cc) saline injection during thoracic epidural catheterization

Treatment:

Procedure: thoracic epidural catheterization