Optical Coherence Tomography Angiography Examinations in Chronic Retinal Artery Occlusion (RAO-OCTA)

Semmelweis University

Status: Completed

Conditions: Retinal Artery Occlusion

Treatments: Device: Optical coherence tomography angiography

Study type: Observational

Funder types: Other

Identifiers

NCT03357146

RAO-OCTA-1253

Details and patient eligibility

About

Purpose of the study is to examine the retinal blood flow in chronic cases of retinal artery occlusion with non-invasive, non-contact optical coherence tomography angiography.

Full description

Occlusion of the retinal arteries is an emergency which causes sudden, painless unilateral vision loss. Loss of blood flow causes ischemic damage to the retina. The extent of damage depends on the area affected.

Following the acute phase of the disease re-canalization occurs and lesser blood flow can be detected usually without functional recovery.

Purpose of the study is to examine the retinal blood flow in chronic cases of retinal artery occlusion.

Standard procedures to examine this disease include retinoscopy following pupil dilation, fluorescein angiography and more recently, optical coherence tomography (OCT).

The latest direction in OCT development was OCT angiography (OCTA) which is a software upgrade that allows detection of blood flow based on motion contrast. Similar to previous OCT machines OCTA is also non-invasive and non-contact and does not require any intravenous agents.

OCT machines are approved in the EU and the US and are not experimental devices.

The device used in this study is the commercially available Zeiss Cirrus HD OCT Angioplex 5000 that operates with spectral-domain technology.

Enrollment: 42 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• central or branch retinal artery occlusion
• at least 6 months of onset
• signed informed consent

Exclusion criteria

• known epilepsy
• incapacity
• presence of optical media opacities that would disturb the imaging
• presence of other retinal diseases that would disturb the evaluation of images

Trial design

42 participants in 2 patient groups

CRA

Description:

Patients with chronic retinal artery occlusion

Treatment:

Device: Optical coherence tomography angiography

Control

Description:

Healthy

Treatment:

Device: Optical coherence tomography angiography