Optical Coherence Tomography in STEMI

Singapore Health Services (SingHealth)

Status: Unknown

Conditions: STEMI

Treatments: Other: Cardiac MRI; Procedure: Index of microcirculatory resistance (IMR); Procedure: Optical coherence tomography (OCT)

Study type: Observational

Funder types: Other

Identifiers

NCT02791178

2015/3034

Details and patient eligibility

About

The overall objective of this research proposal is to use OCT to investigate those morphological culprit plaque characteristics associated with the risk of developing MVO in reperfused STEMI patients.

Full description

The specific research objectives include:

1. To use OCT to determine the type of plaque (plaque rupture, plaque erosion or calcified nodule) most associated with the presence and severity of MVO (as measured by IMR and cardiac MRI).
2. To use OCT to investigate the relationship between the extent of tissue protrusion and the amount of residual stent thrombus with the presence and severity of MVO (as measured by IMR and cardiac MRI).

Enrollment: 35 estimated patients

Sex: All

Ages: 21 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Confirmed STEMI as per the in-charge consultant based on presenting history, ECG and angiogram findings.
2. < 12 hours of onset of chest pain.
3. Ability to provide informed consent

Exclusion criteria

1. Previous myocardial infarction or coronary artery bypass graft surgery
2. Cardiac arrest or cardiogenic shock
3. Inability to advance the OCT catheter or to obtain good image quality
4. Ostial lesions
5. Significant renal impairment
6. Contraindications for cardiac MRI
7. Contraindication for adenosine (for IMR measurement)

Trial design

35 participants in 1 patient group

STEMI patients

Description:

The patients presenting with a STEMI and undergoing PPCI will be screened and approached to participate in this study. All patients to do Optical Coherence Tomography (OCT), Index of Microcirculatory Resistance (IMR) and Cardiac MRI.

Treatment:

Procedure: Index of microcirculatory resistance (IMR)

Other: Cardiac MRI

Procedure: Optical coherence tomography (OCT)