Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease

Case Comprehensive Cancer Center (Case CCC)

Status: Withdrawn

Conditions: Metastatic Cancer; Malignant Mesothelioma; Nonmalignant Neoplasm; Precancerous Condition; Lung Cancer

Treatments: Procedure: histopathologic examination; Procedure: bronchoscopic and lung imaging studies; Procedure: diagnostic bronchoscopy; Procedure: optical coherence tomography

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00733252

CASE1508 (Other Identifier)

P30CA043703 (U.S. NIH Grant/Contract)

CASE-1508-CC483

Details and patient eligibility

About

RATIONALE: Diagnostic procedures, such as optical coherence tomography, may help find and diagnose lung cancer or precancerous cells.

PURPOSE: This phase I trial is studying how well optical coherence tomography of the airway works in detecting abnormal cells in patients undergoing surgery for lung cancer or lung disease.

Full description

OBJECTIVES:

• Correlate optical coherence tomography images of the airway with airway histology.
• Develop an imaging technique to detect premalignant airway epithelial changes (carcinoma in situ, dysplasia) to study the transformation process as well as intervene and prevent the development of lung cancer.

OUTLINE: Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery. All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Undergoing pneumonectomy or lobectomy for malignant or benign lung processes

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics