Optimal Embryonic Stage for Transfer in Poor Responders

Ganin Fertility Center

Status: Unknown

Conditions: Poor Response to Ovulation Induction; Infertility, Female

Treatments: Other: Cleavage stage transfer; Other: Blast stage transfer

Study type: Observational

Funder types: Other

Identifiers

NCT04485819

MH0003

Details and patient eligibility

About

A Prospective cohort study including couples with poor responder females who undergoing ICSI

Full description

Purpose:

To determine the optimal embryonic stage for transfer in poor responders.

Method:

Patients were divided into day 3 transfer group and day 5 transfer group. All cases had the same stimulation protocol and planning to do fresh embryo transfer. Assessments will be at Day 1, Day 3 and Day 5/6 according to Gardner's criteria 1999. Embryological and clinical data were recorded and then analyzed using SPSS (version 23) statistical software.

Enrollment: 300 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• poor responders females with AMH≤ 1.2ng and have ≤ 5 mature oocytes
• couples whose planning to do fresh transfer
• male partners have normal semen parameters according to WHO 2010.

Exclusion criteria

• sperm or oocyte donation
• gestational carriers

Trial design

300 participants in 2 patient groups

Cleavage stage transfer

Description:

Poor responders who transfer their embryos in cleavage stage on day 3

Treatment:

Other: Cleavage stage transfer

Blast stage transfer

Description:

Poor responders who transfer their embryos on blast stage on day 5/6

Treatment:

Other: Blast stage transfer