Optimal Low B-value in Intravoxel Incoherent Motion Diffusion-weighted MR Imaging of the Brain

Tang-Du Hospital

Status: Completed

Conditions: Healthy Volunteers

Treatments: Other: different low b-values distribution

Study type: Observational

Funder types: Other

Identifiers

NCT02411864

TDLL-20140570

Details and patient eligibility

About

Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

Full description

As an improved MRI technique, diffusion-weighted imaging (DWI) is considered the most sensitive for early pathological changes. Perfusion measurement has been shown to improve sensitivity and predictive value for tumor grading and prognosis, also as a predicator of recovery with reperfusion in patients of acute ischemic stroke.Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

Enrollment: 20 patients

Sex: Male

Ages: 25 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• no hypertension or cerebral vascular diseases,
• no systemic metabolic disease;
• no infection or fever;
• no use of corticosteroid drugs;
• no MRI contraindication.

Exclusion Criteria:

Trial design

20 participants in 5 patient groups

Group 1

Description:

Low b=(0,50,150,200)，NEX=(1,3,2,2)

Treatment:

Other: different low b-values distribution

Group 2

Description:

Low b=(0,30,50,100,200)，NEX=(1,3,3,2,2)

Treatment:

Other: different low b-values distribution

Group 3

Description:

Low b=(0,30,60,90,120,150,180,200)，NEX=(1,3,3,3,2,2,2,2)

Treatment:

Other: different low b-values distribution

Group 4

Description:

Low b=(0,30,60,90,120,150,180,200)，NEX=(1,1,1,1,1,1,1,1)

Group 5

Description:

Low b=(0,20,40,60,80,100,120,140,160,180,200)NEX=(1,3,3,3,3,2,2

Treatment:

Other: different low b-values distribution