Optimal Stimulation Parameters to Disrupt Epileptiform Activity

Mass General Brigham

Status: Enrolling

Conditions: Refractory Epilepsy

Treatments: Other: Neurostimulation

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT06141668

2020P002398

R01NS119483 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Open-loop electrical stimulation has been found to reduce spike activity and seizures, but determining the optimal parameters to achieve these effects requires a brute force trial-and-error approach that relies on subjective physician discretion. We will compare the performance of stimulation parameters identified in rodent models to the recommended parameters for neuromodulation used in clinical practice.

Enrollment: 30 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Undergoing intracranial EEG investigation at Massachusetts General Hospital during presurgical epilepsy evaluation

Exclusion criteria

• Baseline spike ripple rate < 0.5/min.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind