Optimisation of ECT Based on ASTI vs Narcotrend

Medical University Innsbruck

Status: Completed

Conditions: Major Depressive Disorder

Treatments: Procedure: Narcotrend

Study type: Interventional

Funder types: Other

Identifiers

NCT04657575

ECT: ASTI vs Narcotrend

Details and patient eligibility

About

The Electro-Convulsion-Therapy (ECT) is a well accepted treatment option in severe depression. The quality of ECT is evaluated basing on minimal seizure duration (>15sec), the sympathic response and the postictal EEG-suppression.

• Page 1 of 3 - For the treatment general anaesthesia is needed. On the other hand anaesthesia strongly influences the quality of the seizure. Standard treatment is to use Anaesthesia to intervention time (ASTI) of 1 to 2 minutes for ideal timing of the electric stimulation.

The aim of the study is to assess if timing of electric stimulation aiming for ar an anaesthesia depth of Narcotrend values 41-64 may provide better convulsion quality than standard approach of using ASTI 1-2 minutes.

Full description

The Electro-Convulsion-Therapy (ECT) is a well accepted treatment option in severe depression. The quality of ECT is evaluated basing on minimal seizure duration (>15sec), the sympathic response and the postictal EEG-suppression.

• Page 1 of 3 - For the treatment general anaesthesia is needed. On the other hand anaesthesia strongly influences the quality of the seizure. Standard treatment is to use Anaesthesia to intervention time (ASTI) of 1 to 2 minutes for ideal timing of the electric stimulation.

The aim of the study is to assess if timing of electric stimulation aiming for ar an anaesthesia depth of Narcotrend values 41-64 may provide better convulsion quality than standard approach of using ASTI 1-2 minutes.

Enrollment: 31 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA 1-3
• Age: 18 -90 years
• Signed informed consent
• Severe depressive disorder

Exclusion criteria

• ASA >3
• Age < 18 or > 90
• denial of the patient
• Impossibility to fix Narcotrend electrodes
• Patients unable to consent
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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31 participants in 2 patient groups

ASTI

No Intervention group

Description:

ECT guided with ASTi 2-4 min

Narcotrend

Active Comparator group

Description:

ECT guided with ECT

Treatment:

Procedure: Narcotrend