Optimising CMR Scan Acquisitions for Novel Equipment/Sequences in Clinical Cardiovascular Populations. (OPTMISE-HFpEF)

University of Leicester

Status: Completed

Conditions: Heart Failure With Preserved Ejection Fraction

Treatments: Other: Participants will undergo a comprehensive CMR scan on either a 1.5- or 3-Tesla scanner

Study type: Observational

Funder types: Other

Identifiers

NCT06311552

0856

Details and patient eligibility

About

The purpose of this study is to develop robust protocols for the optimisation of novel hardware, software and exercise equipment in the magnetic resonance imaging (MRI) environment in various cohorts with cardiovascular disease (CVD) with the first study focusing on those with established heart failure with preserved ejection fraction (HFpEF) or those at risk of or with pre-HFpEF.

Enrollment: 30 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Males or females aged >18 years
• Either a clinical diagnosis of HFpEF, be at risk of or pre- HFpEF

Exclusion criteria

• Absolute contraindication to MRI
• Unable to read/understand English sufficiently to provide informed consent
• Pregnancy
• Unable to consent due to lack of mental capacity
• Current cancer diagnosis and actively undergoing treatment
• Inability to exercise on the MRI ergometer
• Severe claustrophobia

Trial design

30 participants in 1 patient group

CMR scan on either a 1.5- or 3-Tesla scanner

Treatment:

Other: Participants will undergo a comprehensive CMR scan on either a 1.5- or 3-Tesla scanner