Optimising Colorectal Cancer Screening Participation

University of Aarhus

Status: Completed

Conditions: Colorectal Neoplasms

Treatments: Procedure: Invitation procedure

Study type: Interventional

Funder types: Other

Identifiers

NCT04292366

participationCRC2020

Details and patient eligibility

About

The aim of this study is to demonstrate the effectiveness of three and four-staged invitation procedures compared to two-staged procedures by combining pre-notifications and reminders. The RCT will be nested into the Danish colorectal cancer screening programme in the Central Denmark Region including men and women aged 50-74 years. Participants will consecutively be randomized into four arms in a 1:1 ratio. Intervention arm 1 will receive a pre-notification approximately ten days prior to intervention, invitation and one reminder (three-staged intervention), Intervention arm 2 will receive invitation, one reminder after 45 days and a second reminder three months after invitation (three-staged invitation procedure), Intervention arm 3 will receive pre-notification, invitation, reminder after 45 days and reminder after three months (four-staged invitation procedure). Finally, the forth arm will be a control group receiving usual care which invitation and one reminder 45 days after invitation (two-staged invitation procedure). Both pre-notifications and reminders are sent using digital mail.

The main out-come will be participation within 6 months after invitation.

Enrollment: 60,000 patients

Sex: All

Ages: 50 to 74 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Invited for colorectal cancer screening

Exclusion criteria

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

60,000 participants in 4 patient groups

Intervention arm I

Experimental group

Description:

pre-notification approximately ten days prior to intervention, invitation and one reminder (three-staged intervention)

Treatment:

Procedure: Invitation procedure

Intervention arm II

Experimental group

Description:

invitation, one reminder after 45 days and a second reminder three months after invitation (three-staged invitation procedure)

Treatment:

Procedure: Invitation procedure

Intervention arm III

Experimental group

Description:

pre-notification, invitation, reminder after 45 days and reminder after three months (four-staged invitation procedure)

Treatment:

Procedure: Invitation procedure

Control group

Active Comparator group

Description:

invitation and one reminder after 45 days (usual care)

Treatment:

Procedure: Invitation procedure