Optimization of Interval-training in Patients With Type 2 Diabetes

Rigshospitalet

Status: Unknown

Conditions: Diabetes Mellitus, Type 2

Treatments: Behavioral: CON; Behavioral: IW-45; Behavioral: IW-60

Study type: Interventional

Funder types: Other

Identifiers

NCT02601482

H-15008542 - 2

Details and patient eligibility

About

A single bout of Interval-Walking (IW) exercise is superior to energy-expenditure and time-duration matched Continuous Walking (CW) exercise upon improving glycemic control. The time spend with high-intensity (fast) walking is considered to be responsible for the improvements seen, whereas the time spend with low-intensity (slow) walking is considered less important.

This study will assess if IW with maintained fast walking time duration but reduced total time duration (i.e. reduced slow walking time duration) is equally effective as IW with a normal time duration.

Subjects with type 2 diabetes will be included in a crossover, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:

1. Sixty minutes of rest (CON)
2. Sixty minutes of classical interval walking (repeated cycles of 3 minutes of fast and 3 minutes of slow walking; IW-60)
3. Fourty-five minutes of time-reduced interval walking (repeated cycles of 3 minutes of fast and 1.5 minutes of slow walking; IW-45).

After the interventions subjects will undergo a standardized mixed meal tolerance test with assessment of glycemic control.

Enrollment: 14 patients

Sex: All

Ages: 30+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 Diabetes Mellitus
• BMI > 25

Exclusion criteria

• Pregnancy
• Smoking
• Contraindication to increased levels of physical activity
• Eating disorder
• Insulin dependence

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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14 participants in 3 patient groups

Control (CON)

Experimental group

Description:

No exercise intervention.

Treatment:

Behavioral: CON

Normal Interval Walking (IW-60).

Experimental group

Description:

Sixty minutes with repeated cycles of 3 minutes of fast and 3 minutes of slow walking on a treadmill

Treatment:

Behavioral: IW-60

Time-reduced Interval Walking (IW-45)

Experimental group

Description:

Forty-five minutes with repeated cycles of 3 minutes of fast and 1.5 minutes of slow walking on a treadmill

Treatment:

Behavioral: IW-45