Optimization of MRI for Radiation Therapy

University of Michigan Rogel Cancer Center

Status

Completed

Conditions

Cancer Brain

Cancer Head &Neck

Cancer Liver

Cancer Pelvis

Treatments

Procedure: MRI Group

Study type

Observational

Funder types

Other

Identifiers

NCT02045381

HUM00068061 (Other Identifier)

UMCC 2012.113

Details and patient eligibility

About

Currently, appropriate patients undergo MRI imaging with immobilization and sequences optimized for diagnostic radiology purposes. Using a mutual information algorithm, these images are then registered to a treatment planning CT obtained with custom immobilization to minimize intra-and inter-treatment motion and positional variation. This image registration process is time-consuming and introduces additional layers of geometric uncertainty into what should be a highly precise treatment planning process. However, it is necessary, since radiation dose calculations cannot be performed on MRI data due to the lack of crucial density information. The investigator envisions CT-less treatment planning, using only MRI, due to superior imaging characteristics, fully integrated into the radiation oncology clinic. This study will begin this process.

Enrollment

250 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients ≥18 years of age
A working diagnosis of malignancy in the liver, brain, H&N, or pelvis
A plan to treat with radiotherapy

Exclusion criteria

Patients with contraindications to having a contrast enhanced MRI scan. These contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the Radiology Department.