Optimization of Nutritional Therapy in Mechanically Ventilated, Critically Ill Patients. (ONCA)

University of Hohenheim

Status: Completed

Conditions: Critically Ill

Treatments: Other: Indirect Calorimetry

Study type: Interventional

Funder types: Other

Identifiers

NCT03249051

Indirect Calorimetry in ICU

Details and patient eligibility

About

The aim of this study is to investigate whether an individualized determination of energy requirements using indirect calorimetry instead of a formula-based approach leads to an optimized nutritional support and as a consequence to an optimized nutritional status of the critically ill, mechanically ventilated patients measured by the phase angle.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age over 18 years
• mechanical ventilation
• an hospital stay of at least three days at the intensive care unit of the University Hospital of Tübingen
• possibility to perform indirect calorimetry measurements (FiO2 ≤70, PCO2 ≤ 0,5)
• possibility to perform Bioelectrical Impedance Analysis (BIA)
• underlying indication for enteral or/and parenteral nutritional support
• written informed consent from the patient or a legal authorized person

Exclusion criteria

• cardiac pacemaker

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Indirect Calorimetry

Experimental group

Description:

The energy need is being determined by using indirect calorimetry and if necessary, optimized by parenteral, enteral and additive parenteral nutrition.

Treatment:

Other: Indirect Calorimetry

Standard Care

No Intervention group

Description:

This group receives nutrition supply according to the hospital routine ("standard care")