Optimization of PK/PD Target Attainment for Ceftriaxone in Critically Ill Patients With Community-acquired Pneumonia.

Universitaire Ziekenhuizen KU Leuven

Status: Completed

Conditions: Critical Illness; Pharmacokinetics

Study type: Observational

Funder types: Other

Identifiers

NCT03438981

ML8457

Details and patient eligibility

About

WP2.1. PK/PD target attainment Plasma exposure ELF exposure WP2.2. Predictive dosing algorithm WP2.3. ECMO subset

Full description

First, the investigators will document exposure to ceftriaxone in plasma and epithelial lining fluid.

Second, the investigators will try to identify risk factors for not attaining PK/PD target. Based on significant predictors for target non attainment a predictive dosing algorithm will be constructed.

Finally in a small subset of ECMO patients PK exposure will be explored.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pneumonia
• Admitted to an ICU ward
• Treated with ceftriaxone

Exclusion criteria

• Pregnancy
• DNR code 2-3
• Renal replacement therapy