Optimization of PK/PD Target Attainment for Meropenem in Critically Ill Patients With Sepsis

Universitaire Ziekenhuizen KU Leuven

Status: Completed

Conditions: Critical Illness; Pharmacokinetics

Study type: Observational

Funder types: Other

Identifiers

NCT03560557

ML8459

Details and patient eligibility

About

WP1.1. PK/PD target attainment: Plasma exposure, Excretion via urine & ELF exposure; WP1.2. Predictive dosing algorithm; WP1.3. ECMO subset

Full description

First, the investigators will document exposure to meropenem in plasma and epithelial lining fluid. Moreover excretion in urine will be documented.

Second, the investigators will try to identify risk factors for not attaining PK/PD target. Based on significant predictors for target non attainment a predictive dosing algorithm will be constructed.

Finally in a small subset of ECMO patients PK exposure will be explored.

Enrollment: 116 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Severe sepsis or septic shock
• Admitted to an ICU ward
• Treated with meropenem

Exclusion criteria

• eGFR(CKD-EPI) < 70ml/min/1.73m²
• Renal replacement therapy
• Pregnancy
• DNR code 1-3