Optimization of Preventive Effects of Physical Training (SAusE)

Universität des Saarlandes

Status: Completed

Conditions: Primary Prevention, Cardiovascular Risk Factor Management, Size of Response to Training

Treatments: Other: control condition; Other: different training programs

Study type: Interventional

Funder types: Other

Identifiers

NCT01263522

SAusE2011

Details and patient eligibility

About

Health-promoting effects of physical exercise are well-investigated especially for endurance activities. However, for different individuals, positive effects have different sizes, even non-responders are observed. Other forms of training, such as strength training and interval training, are less well investigated. Therefore, a comparative longitudinal training study is warranted to examine differences of preventive effects (outcome measures: ergometric descriptors of physical performance, established risk factors and prognostic factors for cardiovascular diseases) of continuous endurance training, interval training and strength endurance training.

In a second stage, the observed non-responders will perform a different type of training (cross-over). It is expected, that besides a comparative general efficacy evaluation of the three training types, improved recommendations for optimized individualization of training parameters can be formulated.

Enrollment: 266 patients

Sex: All

Ages: 30 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• untrained
• healthy
• non-smoking

Exclusion criteria

• Contraindications for physical activity
• BMI > 30 kg/m2
• resting blood pressure > 160/100 mmHg
• diabetes
• total cholesterol > 300 mg/dl
• maximal oxygen uptake > 50 ml/min/kg for men and > 45 ml/min/kg for women respectively
• other complaints or diseases that might interfere with exercise training

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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266 participants in 4 patient groups, including a placebo group

Endurance training

Experimental group

Treatment:

Other: different training programs

interval training

Experimental group

Treatment:

Other: different training programs

strength endurance training

Experimental group

Treatment:

Other: different training programs

control

Placebo Comparator group

Treatment:

Other: control condition