Optimization of SPECT Imaging (OSCARS)

University of Ottawa Heart Institute

Status: Terminated

Conditions: Coronary Artery Disease

Treatments: Radiation: SPECT/CT processed with Evolution for CardiacTM software

Study type: Interventional

Funder types: Other

Identifiers

NCT01519973

HI Protocol #2008012-01H

Details and patient eligibility

About

Single Photon Emission Computed Tomography (SPECT) is a 3D nuclear medicine imaging technique that is used extensively to study the heart and diagnose heart disease. There are three major limitations in SPECT imaging: attenuation or loss of signal, scattering of the signal in the patient tissues and resolution, where the signal gets blurrier the further the nuclear activity is away from the camera. New software, Evolution for CardiacTM, by GE Healthcare and new cameras with computed tomography (CT) decrease the time needed for images to be obtained while maintaining image quality. Evaluation is needed before they become standard of care.

Enrollment: 64 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Intermediate to high risk patients with coronary artery disease who are scheduled for routine SPECT or PET perfusion imaging

Exclusion criteria

• Pregnancy and breast feeding
• Severe narrowing (stenosis) of the aortic valve
• Severe heart failure

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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64 participants in 1 patient group

Evaluation of technology in SPECT

Other group

Description:

Evaluation of the accuracy of SPECT with new technologies for attenuation correction (AC), scatter correction (SC) and resolution recovery (RR) for assessment of myocardial perfusion using Rb-82 PET as the gold standard.

Treatment:

Radiation: SPECT/CT processed with Evolution for CardiacTM software