Optimization of Therapeutic Drug Monitoring of Vancomycin in Pediatric Patients With an Implanted Port Catheter

Universitaire Ziekenhuizen KU Leuven

Status: Terminated

Conditions: Catheter Related Blood Stream Infections

Treatments: Procedure: Extensive flushing of the port catheter

Study type: Interventional

Funder types: Other

Identifiers

NCT03720132

S20140519

Details and patient eligibility

About

The goal of this study is to verify whether extensive flushing of the port catheter in patients with catheter related blood stream infection will lead to correct vancomycin trough levels, taken via the port catheter and compared with simultaneously taken peripheral samples.

Full description

In this study, extensive flushing of the port catheter prior to blood sampling to determine vancomycin trough levels, will be compared with normal flushing. To ascertain correctness of the trough levels taken via the central catheter, sampling will occur through a peripheral catheter simultaneously.

Flushing will be done with sodium chloride 0.9 % solution.

Enrollment: 10 patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pediatric patients with a port catheter
• Treated with systemic vancomycin and/or vancomycin "lock"

Exclusion criteria

• Age > 18 years
• Active downgrading of care

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Patients with port catheter: flushing

Experimental group

Description:

In patients with a catheter-related blood stream infection (CRBSI) and a port catheter, being treated with vancomycin intravenously, we will flush the catheter with 30 ml of sodium chloride 0.9 % prior to blood sampling to determine vancomycin concentrations, in order to decrease residuel vancomycin in the port.

Treatment:

Procedure: Extensive flushing of the port catheter