Optimization of Thoracic Aortic MRI Acquisition Sequences for the Quantification of Diagnostic-assisting Biomarkers (SEQUOIA)

Assistance Publique - Hôpitaux de Paris

Status: Not yet enrolling

Conditions: Healthy Volunteers

Treatments: Other: MRI calibration

Study type: Interventional

Funder types: Other

Identifiers

NCT05545410

APHP211541

Details and patient eligibility

About

The main objective is to optimize MRI acquisition and image post-processing protocols in order to define the best compromise between short scan time and image quality (contrast between different tissues, spatial and temporal resolutions) high enough to accurately measure morphologic, hemodynamic and structural aortic biomarkers.

Full description

This Magnetic Resonance imaging study of the thoracic aorta aims to: 1- enhance patient comfort during the examination, shorten appointment waiting times and overall reduce MRI cost, and 2- provide a reliable diagnosis and risk assessment of aorta-related diseases occurring in hypertension, obesity or diabetes but also throughout normal aging.

The impact of MRI acquisition innovations on the measurement of biomarkers that are extracted from image post-processing software and therein on disease characterization (normal values, severity thresholds, etc.) must be systematically reevaluated. More specifically, the investigators design image acquisition and automated image processing methods to reduce operator variability. This study will optimize thoracic aortic MRI acquisition sequences for the quantification of diagnostic-assisting biomarkers in a healthy population.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subject aged between 20 and 35 or between 50 and 70 (limits included)
• BMI < 30 kg/m²
• Asymptomatic subject
• Having given informed, free and written consent
• Affiliated to a French social security scheme or entitled

Exclusion criteria

• Contraindication to MRI (claustrophobia, presence of a metallic foreign body)
• Pregnant or breastfeeding woman
• Known cardiac pathology
• Personal cardiovascular history
• Person deprived of liberty by court decision or benefiting from legal protection (under guardianship or curatorship)
• Abuse of alcohol or narcotics
• Subject under AME
• Participation in another interventional research involving the human person or being in the exclusion period at the end of a previous research involving the human person

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

healthy volunteers

Other group

Treatment:

Other: MRI calibration