Optimization Strategy of Carotid Artery Stenosis (COAS-CAS)

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Enrolling

Conditions: Carotid Artery Stenosis

Treatments: Diagnostic Test: CTA; Diagnostic Test: Ultrasound; Procedure: Carotid revascularization; Diagnostic Test: PET/MRI; Diagnostic Test: MRI-PWI

Study type: Observational

Funder types: Other

Identifiers

NCT05629000

PUMCH-CAS-006

Details and patient eligibility

About

The goal of this observational study is to learn about how to utilize multiple evaluation techniques in carotid artery stenosis patients for optimizing assessment of diagnosis and treatment strategy.

The main questions it aims to answer are:

• Identify best strategy that use multi-modal MRI and CT to assess patients' cerebral lesions and perfusion.
• Identify best strategy that use multi-modal MRI, PET-MRI ultrasound and CT to assess components and characters of patients' carotid plaques.

Participants will accept imaging examination before and after surgery. And doctors will collect basic characteristics, imaging results and biological samples of patients for analysis.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. patients with severe stenosis (≥50%) or near-occlusion diagnosed by computed tomographic angiogram;
2. patients received carotid endarterectomy at Peking Union Medical College Hospital

Exclusion criteria

(1) Any contraindication to image examination; (3) refuse to sign the Informed consent.

Trial design

1,000 participants in 1 patient group

Carotid artery stenosis

Description:

patient with carotid artery stenosis

Treatment:

Procedure: Carotid revascularization

Diagnostic Test: CTA

Diagnostic Test: Ultrasound

Diagnostic Test: PET/MRI

Diagnostic Test: MRI-PWI