Optimized Characterization of Takotsubo Syndrome by Obtaining Pressure Volume Loops (OCTOPUS)

University of Luebeck

Status: Completed

Conditions: Takotsubo Syndrome

Treatments: Diagnostic Test: Measurements of left ventricular pressure and volume

Study type: Interventional

Funder types: Other

Identifiers

NCT03726528

17-078

Details and patient eligibility

About

Aim of this prospective study is to assess the pathophysiology of Takotsubo Syndrome by obtaining pressure volume loops with conductance catheters, which allows detailed conclusions regarding systolic and diastolic hemondynamics and subsequently regarding potential underlying mechanisms

Enrollment: 25 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed Takotsubo syndrome according to current diagnostic criteria including complete normalization of left ventricular function during follow-up
• Sinus rhythm during invasive measurements
• Age ≥18 years
• Written informed consent

Exclusion criteria

• Cardiogenic shock
• Signs of myocarditis or myocardial infarction with spontaneous lysis of thrombus in cardiac magnetic resonance imaging
• Pregnancy
• Participation in another trial

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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25 participants in 1 patient group

Experimental intervention

Experimental group

Treatment:

Diagnostic Test: Measurements of left ventricular pressure and volume