Optimizing Diagnosis Of Primary Aldosteronism (ODPA)

Chongqing Medical University

Status: Completed

Conditions: Primary Aldosteronism

Study type: Observational

Funder types: Other

Identifiers

NCT02755519

ODPA 2016

Details and patient eligibility

About

To optimize the confirmatory tests for primary aldosteronism.

Full description

In this study, the investigators aim to optimize the three confirmatory tests: salt loading, captopril challenge and fludrocortisone suppression, and to confirm a better choice of confirming testing for single or combined diagnosis of primary aldosteronism. Additionally, the investigators plan to collect blood and tissue samples of PA patients for genetic testing, and to proceed a long-term follow-up for further investigating the mechanism underlying PA and evaluating the cardio-cerebrovascular complications risk.

Enrollment: 300 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• With hypertension;
• With adrenal diseases

Exclusion criteria

• Pregnant or during lactation period;
• Under 18 yr;
• BMI ≤ 19 or ≥ 35
• With Cancer medical history
• Been through cardiovascular diseases in the past 3 months;
• Been through malignant arrhythmia, respiratory muscle paralysis or skeletal muscle paralysis caused by hypokalemia.

Trial design

300 participants in 2 patient groups

Primary Aldosteronism

Description:

Those with hypertension, and with or without hypoglycemia; Those with PAC/PRC≥42.95 pg·mL-1/µIU·mL-1

Non-Primary Aldosteronism

Description:

Those with Primary Hypertension; Those with adrenal diseases except for Primary Aldosteronism