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Optimizing HPV Vaccine Introduction in Shanghai, China

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University of Michigan

Status

Terminated

Conditions

Vaccine Refusal

Treatments

Behavioral: Cervical cancer
Behavioral: Recommendation for children 18 years old
Behavioral: Standard age information
Behavioral: Information about infectious disease
Behavioral: Blank information about communicability
Behavioral: Broadened information about cancers
Behavioral: Recommendation for children 12 years old
Behavioral: Information about STDs

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT03972813
K01AI137123 (U.S. NIH Grant/Contract)
HUM00155864

Details and patient eligibility

About

Within low, middle, and upper income countries, low vaccine coverage results from both obstacles to vaccine access and low confidence in vaccine programs. Thus, it is critical to determine how best to enhance trust in vaccines as increasing numbers of vaccines are recommended for use. Even though the context accompanying the initial roll-out of a vaccine can have a large impact on people's perceptions of the vaccine and the corresponding disease, it is not clear how to best introduce a vaccine to increase public confidence and enhance uptake. The US roll-out of the human papillomavirus (HPV) vaccine framed HPV as a sexually transmitted infection, which proved to be an impediment to efforts to increase vaccine uptake >10 years after its introduction. This study will use an educational experiment, where parents of children will be exposed to information about the HPV vaccination in different ways. Parents will be introduced to the HPV vaccine through different scenarios with varying emphases (i.e., age at vaccination, types of transmission, type of cancer prevention). The aim will be to determine how the framing of the HPV vaccination across several dimensions affects short-term willingness to receive it.

Enrollment

1,021 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Parents of children 2-18 years old.

Exclusion criteria

  • None

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Factorial Assignment

Masking

None (Open label)

1,021 participants in 18 patient groups

cervical cancer - sexually transmitted (STD) - standard
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cervical cancer. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China.
Treatment:
Behavioral: Information about STDs
Behavioral: Standard age information
Behavioral: Cervical cancer
cervical cancer - STD - 12 years old (y.o.)
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cervical cancer. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine.
Treatment:
Behavioral: Information about STDs
Behavioral: Recommendation for children 12 years old
Behavioral: Cervical cancer
cervical cancer - STD - 18 y.o.
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cervical cancer. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine.
Treatment:
Behavioral: Information about STDs
Behavioral: Recommendation for children 18 years old
Behavioral: Cervical cancer
cervical cancer - infectious - standard
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cervical cancer. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China.
Treatment:
Behavioral: Information about infectious disease
Behavioral: Standard age information
Behavioral: Cervical cancer
cervical cancer - infectious - 12 y.o.
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cervical cancer. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine.
Treatment:
Behavioral: Recommendation for children 12 years old
Behavioral: Information about infectious disease
Behavioral: Cervical cancer
cervical cancer - infectious - 18 y.o.
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cervical cancer. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine.
Treatment:
Behavioral: Information about infectious disease
Behavioral: Recommendation for children 18 years old
Behavioral: Cervical cancer
cervical cancer - blank - standard
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cervical cancer. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China.
Treatment:
Behavioral: Blank information about communicability
Behavioral: Standard age information
Behavioral: Cervical cancer
cervical cancer - blank - 12 y.o.
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cervical cancer. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine.
Treatment:
Behavioral: Recommendation for children 12 years old
Behavioral: Blank information about communicability
Behavioral: Cervical cancer
cervical cancer - blank - 18 y.o.
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cervical cancer. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine.
Treatment:
Behavioral: Blank information about communicability
Behavioral: Recommendation for children 18 years old
Behavioral: Cervical cancer
many cancers - STD - standard
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China.
Treatment:
Behavioral: Information about STDs
Behavioral: Broadened information about cancers
Behavioral: Standard age information
many cancers - STD - 12 y.o.
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine.
Treatment:
Behavioral: Information about STDs
Behavioral: Recommendation for children 12 years old
Behavioral: Broadened information about cancers
many cancers - STD - 18 y.o.
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine.
Treatment:
Behavioral: Information about STDs
Behavioral: Broadened information about cancers
Behavioral: Recommendation for children 18 years old
many cancers - infectious - standard
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China.
Treatment:
Behavioral: Broadened information about cancers
Behavioral: Information about infectious disease
Behavioral: Standard age information
many cancers - infectious - 12 y.o.
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine.
Treatment:
Behavioral: Recommendation for children 12 years old
Behavioral: Broadened information about cancers
Behavioral: Information about infectious disease
many cancers - infectious - 18 y.o.
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine.
Treatment:
Behavioral: Broadened information about cancers
Behavioral: Information about infectious disease
Behavioral: Recommendation for children 18 years old
many cancers - blank - standard
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China.
Treatment:
Behavioral: Broadened information about cancers
Behavioral: Blank information about communicability
Behavioral: Standard age information
many cancers - blank - 12 y.o.
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine.
Treatment:
Behavioral: Recommendation for children 12 years old
Behavioral: Broadened information about cancers
Behavioral: Blank information about communicability
many cancers - blank - 18 y.o.
Experimental group
Description:
The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine.
Treatment:
Behavioral: Broadened information about cancers
Behavioral: Blank information about communicability
Behavioral: Recommendation for children 18 years old

Trial documents
1

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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