Optimizing Propofol in Obese Patients
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About
An accurate dosage of anesthetics during surgery is important. Usually this is achieved through close observation of the patient, but a new monitor (CSM-monitor) can measure the level of anesthesia more closely.
In obese patients dosage of drugs is difficult due to the change in body composition. The CSM-monitor may provide a more accurate dosage of propofol (an anesthetic agent) during surgery, and as a consequence of that, also reduce the postoperative need for analgesics.
Main objective: To optimise propofol dosing in obese patients undergoing hysterectomy.
Main hypothesis: Monitoring the depth of anesthesia using the CSM-monitor reduces time to opening eyes in obese patients after hysterectomy in propofol anesthesia.
Secondary hypotheses: CSM-monitoring reduce propofol dose in obese patients undergoing hysterectomy. Patients with a high CSM-level during hysterectomy have higher postoperative consumption of analgesics. Supplementary, an algorithm for the dose of propofol that most frequently results in a CSM-level between 40 and 60 is calculated.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Elective abdominal non-laparoscopic hysterectomy
- Age > 18 years
- ASA physical status I-III
- Body Mass Index 30 or above
Exclusion criteria
- Allergic towards propofol
- Daily consumption of benzodiazepines (more than at nighttime), opioids or amphetamine preoperatively.
- Disease with expected EEG-abnormality or impaired auditory function: Epilepsy, deafness, previous neurosurgery, previous or actual neurologic disease with neurologic deficit.
Trial design
Primary purpose
Allocation
Interventional model
Masking
38 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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