Oral Administration of Colostrum to Premature Babies: Impact on the Oral Microbiota

University of California (UC) Davis

Status: Completed

Conditions: Changes in the Oral Microbiota

Treatments: Other: Colostrum

Study type: Interventional

Funder types: Other

Identifiers

NCT02306980

531791

Details and patient eligibility

About

Oropharyngeal administration of mother's colostrum to premature infants has been proposed as a stimulus to the oropharyngeal lymphatic tissues to decrease the incidence of pneumonia and sepsis, particularly in intubated babies. We propose to study the impact of this intervention on the composition of the oral microbiota.

Enrollment: 12 patients

Sex: All

Ages: 12 hours to 7 days old

Volunteers: No Healthy Volunteers

Inclusion criteria

• premature infant with birth weight < 1500
• intubated in the first 48 hours of life
• available maternal colostrum

Exclusion criteria

• lethal condition

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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12 participants in 2 patient groups

Colostrum

Experimental group

Description:

Colostrum administration

Treatment:

Other: Colostrum

Control

No Intervention group

Description:

Routine care